The best-performing stocks of 2022 have shrugged off global market weakness.

These stocks have generated the best returns so far in 2022.

The S&P 500 declined 4.2% in August as fears over persistently high inflation, aggressive Federal Reserve interest rate hikes, and an uncertain global economic outlook have investors fleeing risk assets. The S&P 500 is now down 17% year to date, but a handful of top-performing stocks have bucked the bearish trend. Top performers include several oil and gas stocks benefiting from surging energy prices and health care stocks with unique bullish catalysts. Here are the 10 best-performing stocks of 2022 among companies that trade on major U.S. exchanges and have market capitalizations of at least $1 billion. Returns are total returns, meaning they reflect the impact of any dividends and are through Aug. 31.