Genmab (NASDAQ: GMAB) is a biotechnology firm based in 1999 by Florian Schönharting. The corporate focuses on monoclonal antibody programs, which can be utilized in numerous therapies. Most notably, the corporate has seen its antibody expertise make it into 5 authorized therapies available on the market so far. These merchandise embrace Tivdak, Darzalex, Rybrevant, Kesimpta, and Tepazza. Regardless of already having profitable merchandise available on the market, the corporate doesn’t simply relaxation on its laurels. Genmab has a number of different thrilling new therapies within the analysis and improvement pipeline between themselves and an array of partnerships with different corporations they’ve fashioned.
On this article, I’ll present that Genmab is a reasonably valued firm on the rise, with huge potential upside. Not like a lot of its rivals, Genmab has the benefit of getting its propriety antibody therapies available on the market within the type of a number of different drug therapies offered by themselves or by different corporations as a part of a partnership. This permits Genmab to proceed its analysis and improvement efforts whereas nonetheless producing a revenue. One other issue to think about is the standing of the oncology drug market; as one of many largest and most various areas within the healthcare trade there exists an enormous alternative for corporations to develop therapeutics for 1000’s of potential targets all with life-saving potential. Due to this fact, any firm capable of produce a viable drug for quite a lot of beforehand untreatable cancers has large freedom to set the value level of their medicine. Because of these causes, I imagine Genmab’s present market portfolio and future pipeline help the case for robust development over the approaching quarters.
Along with being a frontrunner within the improvement of antibody-drug expertise, Genmab additionally holds a declare to a number of medicine which are already available on the market. These medicine deal with plenty of ailments, from particular cancers to autoimmune problems, and have served as a gradual income stream for the corporate. It is because it constantly pushes the envelope by way of analysis and improvement to get much more merchandise by the market.
An antibody drug-conjugate, Tivdak is a prescription remedy used to deal with adults with cervical most cancers. Tivdak is offered by Seagen, who pays Genmab a proportion primarily based on the inclusion in Genmab’s monoclonal antibody expertise. In Q3 of 2021, it was reported that Tivdak recorded $366.5 million in gross sales and over $1 billion in whole gross sales since its launch available on the market.
This drug is a prescription remedy used to deal with non-small-cell lung most cancers. The drug is a target-specific antibody that seeks out cancer-causing receptors and blocks them so as to cease development. The drug has carried out effectively and is anticipated to generate revenues in extra of $4 billion by 2028.
This drug breaks away from the extra profitable most cancers remedy market and was as a substitute developed to deal with relapsing types of A number of Sclerosis. Kesimpta makes use of Genmab’s antibody expertise to deplete MS-causing B cells, successfully treating the illness. Gross sales for this drug reached $147 million in 2021.
One other departure from the extra profitable oncology market, Tepazza is a drugs for people who find themselves by Thyroid Eye Illness (TED). The drug works by turning on the eyes’ receptor change when the illness runs awry, which causes swelling. As the one FDA-approved remedy for TED, Tepezza raked in an astonishing $1.5 billion in 2021.
This drug is a breakthrough remedy for a particular kind of blood most cancers known as a number of myeloma. As a monoclonal antibody, Darzalex treats most cancers by attaching itself to the most cancers cells and both eradicating the illness itself or triggering the physique’s immune system to do the job. As of Q3 2021, it was reported that the drug had generated almost $1.6 billion in gross sales.
Partnership With Synaffix
In 2022 Genmab reached an settlement with Synaffix, which gave them entry to its Antibody Drug-Conjugates (NYSE:ADC) applied sciences. The partnership grants Genmab the rights to make the most of the ADC applied sciences for one particular drug improvement. Nonetheless, the settlement additionally provides them the choice for the worldwide improvement and commercialization of the ensuing ADC’s from that improvement, which might be extremely worthwhile. Genmab is accountable for the entire subsequent R&D prices. What the partnership affords is huge potential. Synaffix brings a cutting-edge ADC expertise platform, and Genmab makes use of that with its personal antibody improvement capabilities.
To safe the rights to Synaffix’s ADC platforms, Genmab paid the corporate $4.5 million upfront. Moreover, on a focused foundation, Synaffix has the suitable to implement extra funds primarily based on sure milestones which are hit throughout the improvement of its therapies. The entire deal might be value as a lot as $415 million. It is a drop within the bucket in comparison with what the event of a breakthrough most cancers remedy might be value. By combining each applied sciences, Genmab has an actual probability of growing a blockbuster drug.
Beginning in 2019, the corporate posted $805.5 million in income. In 2020 that quantity greater than doubled to $1.66 billion Within the earlier 12 months 2021, income had a slight lower to $1.3 billion, nonetheless sustaining the numerous development we noticed throughout tumultuous 2020. As all of this income comes within the type of funds from different corporations using Genmab’s expertise, almost each greenback of the above-mentioned income counts as firm revenue, making it a really profitable enterprise. In 2019 Genmab had $164.5 million in whole liabilities that greater than doubled in 2020 to $331.9 million. Final 12 months throughout 2021, Genmab has been capable of maintain long-term debt largely underneath management with solely a slight improve to $371.9 million.
Genmab has additionally managed to extend the corporate’s money and money equivalents. In 2019 the corporate closed the 12 months with $533.2 million. In 2020 that quantity doubled to over to $1.19 billion. In 2021 it saved growing to a powerful $1.37 billion. The significance of money can’t be understated on the subject of biotechs the place elevated entry to capital permits them to help each the event and advertising of pipeline merchandise. Between 2020 and 2021 Genmab has a % change in liabilities of 11.4% versus a rise in money of 14% demonstrating that money development has outpaced the rise in liabilities throughout the previous 12 months. This doesn’t even keep in mind the true change in money and liabilities with money growing by over $180 million and legal responsibility by solely $40 million, over 4x much less. All of those figures level to an organization that has a strong stability sheet with the capital required to stimulate future development.
Genmab is a biopharmaceutical firm with massive desires. It has endeavored to discover a remedy for as many variations of cancers as it will probably. It has a really optimistic monitor report for growing efficient therapies for oncological ailments, together with a bunch of others. Their monoclonal antibody platform is without doubt one of the finest available on the market, demonstrated by the variety of confirmed therapies already available on the market using their expertise. From a enterprise perspective, the numbers inform a story of an organization that has outlined success and elevated its metrics 12 months after 12 months. With savvy partnerships and dynamic analysis and improvement, they may very effectively be on the quick monitor for much more breakthrough remedy applied sciences. This can solely make them extra profitable within the years to return. For these causes, I imagine the corporate represents a purchase for biotech buyers seeking to increase their publicity to the rising oncology area.